Transdermal delivery of multiple antibiotics using GMP compliant low molecular weight PVA PVP hydrogel forming MAPs
Andang Miatmoko, PhD – Lecturer, Airlangga University; Maria Galleri – Student, Queen's University Belfast; Ryan Donnelly, PhD – Professor, Queen's University Belfast
Postdoc Research Fellow Queen's University Belfast Belfast, Northern Ireland, United States
Introduction: Hydrogel-forming microarray patches (HFMAPs) can deliver high doses of actives such as antibiotics transdermally [1]. Dose is not limited by needle loading because drug is stored in separate reservoirs and released when crosslinked hydrogel swells after absorbing dermal interstitial fluid [1]. For long-term use, biodegradable, biocompatible GMP-grade polymers are required, as leached polymer ( >50 kDa) may evade glomerular filtration and accumulate [2]. We therefore prepared HFMAPs from crosslinkable, low-molecular-weight, injectable-grade polymers for minimally invasive, low-risk transdermal delivery.
Learning Objectives:
Describe the composition and fabrication of HFMAPs for antibiotic delivery
Explain how crosslinking time influences swelling mechanical strength and drug permeation through skin
Evaluate potential clinical benefits of sustained transdermal antibiotic delivery using HFMAPs
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