Stimuli-responsive antimicrobial electrospun wound dressings

Michael Malkoch – professor, Division of Coating Technology, Royal Institute of Technology (KTH); Reshma Ramachandran – postdoctoral researcher, Department of Chemistry, Science for Life Laboratory, Stockholm University; Georgios Sotiriou – professor, Department of Chemistry, Science for Life Laboratory, Stockholm University; Alexandra Teleki – professor, Department of Pharmacy, Science for Life Laboratory, Uppsala University

Introduction:

Chronic wounds arise when the inflammation phase of healing is disrupted, often due to impaired circulation and persistent infection. Conventional antibiotic‑releasing wound dressings place selective pressure on bacteria within the wound microenvironment, thereby promoting the emergence of antimicrobial resistant pathogens and complicating treatment¹.
This study aims to develop an antibiotic‑free antimicrobial strategy by incorporating reactive‑oxygen‑species (ROS)-producing nanoparticles (NP) into electrospun wound dressings with the goal of reducing bacterial burden in the wound environment.