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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

sHDL Remodeling: Impact of Lipid Composition, Acyl Chain Length, Charge, and Cholesterol

Artturi Koivuniemi – Academy Research Fellow, University of Helsinki; Tuomas Niemi-Aro – Laboratory Engineer, University of Helsinki
Introduction: Atherosclerosis is a leading cause of mortality, with current therapies inadequately addressing residual cardiovascular risks. HDL-mediated reverse cholesterol transport is a promising target, yet therapies increasing HDL-C often fail clinically. This highlights the need for innovative synthetic HDL (sHDL) nanoparticles, incorporating phospholipids and apoA-I mimetic peptides like 22A. While the peptide is well-characterized, the impact of lipid composition on s-HDL properties and remodeling efficacy remains less understood.

Learning Objectives:

  • explain how lipid composition, acyl chain length, surface charge, and cholesterol affect size and Tm of nanodiscs.
  • understand the correlation between Tm and remodeling efficiency of sHDL particles on endogenous HDL in human plasma.