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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Senotherapeutic Nanoformulations for the Treatment of Vascular Ageing

Rita Sá Ferreira – PhD, CNC-UC; Marta Barão – PhD Student, CNC-UC; Joana Padrão – MSc, CNC-UC; Renata Castro – MSc, CNC-UC; Johan Panek – PhD, Newcastle University; Edward Fielder – Post Doctoral Researcher, Newcastle University; Javier Huete-Acevedo – PhD Student, University of Valencia; Viktor Korolchuk – PI, Newcastle University; Consuelo Borrás – PI, University of Valencia; Patricia Pitrez – Post Doctoral Researcher, CNC-UC; Lino Ferreira – PI, CNC-UC
Introduction:

Vascular ageing is driven by the accumulation of senescent endothelial cells (ECs), which exhibit irreversible cell-cycle arrest and a pro-inflammatory secretory phenotype (SASP) (1). These cells act as the underlying foundation for systemic physiological decline and fuels progression of cardiovascular diseases (CVDs) (2), a critical challenge to global health. Current senotherapeutics often lack cell-type specificity, leading to off-target risks. We propose biomimetic nanoformulations designed to selectively modulate senescent ECs to improve vascular dysfunction (3).

Learning Objectives:

  • Explain senescent ECs modulation via nanoformulations.
  • Discuss a pathway as senescence target.