Graduate Research Assistant University of Kansas Lawrence, Kansas, United States
Introduction: The current gold standard for management of hyperglycemia is subcutaneous administration of insulin. An oral delivery platform for insulin is of interest due to convenience of dosing. Free insulin delivered orally, however, encounters psychological hurdles such as enzymatic degradation and mucosal malabsorption in the stomach and gastrointestinal (GI) tract. Due to this, an insulin-loaded casein-stabilized Pickering Emulsion (CPE-INS) was fabricated to protect insulin from GI enzymatic degradation and facilitate enhanced mucosal penetration for systemic absorption following oral delivery. In this study, we report the loading efficiency of insulin, and stability of the formulation.
Learning Objectives:
Demonstrate Pickering emulsions are stable carriers for protein therapeutics such as insulin
