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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Self-assembled hyaluronic acid nanoparticles for targeted co-delivery of betulinic acid and paclitaxel in cancer

Sanyog Jain – Professor, Pharmaceutics, NIPER, Mohali
Introduction:

Triple negative breast cancer is the most aggressive phenotype, with a heightened propensity for metastasis, relapse, and poor survival rates. Paclitaxel (PTX) is widely used but limited by resistance and tumor heterogeneity. Betulinic acid (BtA) induces mitochondrial apoptosis and sensitizes tumor to chemotherapy. Hence, this study aims to explore the potential of hyaluronic acid (HA) prodrug-based self-assembled nanoparticles (HA-BtA-PTX NPs) for tumor targeted co-delivery of BtA and PTX . The proposed delivery system provide active tumor targeting due to the high binding affinity of HA to the CD44 receptor.

Learning Objectives:

  • Synthesize and characterize HA-BtA conjugates and self-assembled nanoparticles.
  • Analyze CD44-mediated uptake and enzyme-responsive drug release behavior.
  • Evaluate therapeutic efficacy and synergistic anticancer effects in-vitro and in-vivo.