Engineering Peptide-Decorated Lipid Nanoparticles for Active Tumor-Directed RNA Delivery

Esther Broset – RNA Design Manager, RNA Design Department, CerTest Biotec S.L.; Diego Casabona Agudo – API Manager, CerTest Biotec S.L.; Diego De Miguel, PhD – LNP Department Manager, Certest Biotec SL; Javier Gimenez-Warren – Chief Technical Officer, Lipids Department, Certest Pharma; Juan Enrique Martinez Olivan – Chief Scientific Officer, Certest Biotec S.L.; Elena Mata – Assays and Evaluations Manager, Assays and Evaluations Department, CerTest Biotec S.L.; Esther Perez – Project Manager, CerTest Biotec S.L.; Andrei Mihai Stoian, PhD Student – Assays and Evaluations Junior Researcher, Certest Biotec S.L.

Introduction: RNA-based approaches are changing the landscape of cancer therapy. Precise active targeting is essential for delivering RNA therapeutics to extrahepatic cell populations. Here, we introduce a modular platform able to generate a wide array of ligand-guided lipid nanoparticles (LNPs) with one or multiple cargos and/or ligands to use as high precision cancer treatments..