N-acetylcysteine spray dried powders with antioxidant activity for pulmonary delivery
Matteo Incerti – Associate Professor, University of Parma; Paolo Pio Mazzeo – Associate Professor, University of Parma; Immacolata Maresca – Laboratory Technician, University of Ferrara; Gianni Sacchetti – Full Professor, University of Ferrara; Alessandra Rossi – Associate Professor, University of Parma
Postdoctoral Research Fellow University of Parma, Italy
Introduction: N-acetylcysteine (NAC), a L-cysteine pro-drug, is widely used as a mucolytic agent and as an antidote for acetaminophen poisoning1. Beyond these established purposes, NAC presents antioxidant and anti-inflammatory properties, supporting its recent repurposing as adjuvant therapy in chronic pulmonary diseases2. Despite the low oral bioavailability3, it is marketed in oral dosage forms, while additional formulations are available as solutions for oral inhalation. In this study, NAC spray dried (SD) powders with antioxidant activity were developed for pulmonary delivery.
Learning Objectives:
Formulation of high payload NAC spray dried powders
In vitro antioxidant activity assessment following spray drying process
Stability assessment of dry powders for pulmonary delivery
