Enhancing the Performance of Lipidic Nanosystems with Choline-Based Ionic Liquids

Luis Oliveira – Student, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Madalena Batista – Student, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Carlos Ventura – Student, Escola Superior de Tecnologia do Barreiro, Instituto Politécnico de Setúbal, Setúbal, PORTUGAL; Margarida Caroço – Student, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Raquel Mendes – Student, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Marta B. Martins – Student, CBIOS, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; João Vieira – PhD Student, Universidad de Alcalá, Departamento de Ciências Biomédicas, Ctra, Madrid-Barcelona, Madrid, ESPAÑA; CBIOS, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Nuno Saraiva – Integrated Member, CBIOS, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Catarina Pereira-Leite – Integrated Member, CBIOS, ECTS, Universidade Lusófona, Lisboa, PORTUGAL; Catarina Rosado – Integrated Member, CBIOS, ECTS, Universidade Lusófona, Lisboa, PORTUGAL

Introduction: Controlled transcutaneous delivery remains a major challenge. Formulation strategies that leverage the advantages of lipid-based nanosystems have been developed to surpass these limitations, but challenges during formulation and low colloidal stability remain [1,2]. Bio-based choline-derived ionic liquids (ILs) are gaining prominence as green, well-tolerated ingredients and show promise for improving nanocarriers loading, stability, and release [2,3]. We aimed to investigate the applicability of choline-based ILs as functional excipients in the formulation design of lipid-based nanosystems for the topical delivery of ferulic acid (FA).