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Skin and Mucosal Delivery (Focus Group – SMD)

Electrospun in situ cross-linked nanofibers for sustained and triggered drug delivery in wound healing

David Juriga – Postdoctoral Researcher, SciLifeLab, Dept. of Chemistry, Stockholm University; Georgios Sotiriou – Professor, SciLifeLab, Dept. of Chemistry, Stockholm University
Introduction:

Wound infections caused by multidrug-resistant bacteria severely impede the healing process [1]. Effective wound healing therapies therefore demand drug delivery systems that offer sustained and localized release. This study presents the development of electrospun polymer fibers that are in situ cross-linked to enhance stability and control drug release kinetics. These fibers incorporate flame spray pyrolysis (FSP)-made inorganic nanoparticles alongside lipid nanoparticles, or drugs for sustained and stimuli-responsive delivery.

Learning Objectives:

  • Describe how in situ cross-linking can enhance sustained drug release in electrospun fiber systems.
  • Explain the role of nanoparticles in achieving on-demand, triggered release.
  • Identify advantages of integrating lipid nanoparticles into fiber-based drug delivery platforms.