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Skin and Mucosal Delivery (Focus Group – SMD)

Architectural Control of Hydration and Drug Permeation in Monoaxial and Coaxial Electrospun Nanofibres

Adeola Adebisi – Senior Lecturer, University of Huddersfield; Kofi Asare-Addo – Reader in Pharmaceutics, University of Huddersfield
Introduction:

Electrospun fibres have been widely explored for controlled drug delivery. However, burst release remains common and depends strongly on polymer distribution and fibre architecture [1,2]. In this study, we compare monoaxial (blended) and coaxial (core-shell) PVA–PEO nanofibers incorporating nicotinamide, using PEO molecular weight as an adjustable parameter. Novel UV imaging was integrated with conventional characterisation to link architecture, hydration behaviour, and release and permeation performance.

Learning Objectives:

  • Develop design-driven strategies for controlled transdermal drug delivery.
  • Correlate structure, hydration behaviour, and solid-state properties with release performance.
  • Apply UV imaging to study the permeation of electrospun transdermal patches.