Scalable production of bioresorbable, monodisperse, injectable microparticles using IN-AIR MICROFLUIDICS

Yuanyuan Liao – R&D, IamFluidics B.V.; Iris Lambrichs – R&D, IamFluidics B.V.; Don Hertsig – R&D, IamFluidics B.V.; Thijs Duursma – R&D, IamFluidics B.V.; Jenny Parraga – R&D, IamFluidics B.V.; Lisette van Lith – R&D, IamFluidics B.V.; Jieke Jiang – Assistant Professor, University of Twente; Claas Willem Visser – Professor, IamFluidics B.V. / University of Twente; Bahar Yeniad – Global Senior Business Development Manager, Corbion

Introduction: Injectable microparticles are widely used in long-acting drug delivery and regenerative aesthetic applications. However, conventional production methods often yield polydisperse, irregular, or non-degradable particles with poor injectability and associated safety concerns. These limitations can lead to nozzle clogging, tissue irritation, and uncontrolled foreign body responses. In this work, we demonstrate the potential of IN-AIR MICROFLUIDICS as a scalable approach to produce highly uniform, bioresorbable microparticles with controlled properties.