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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Surface modification of flame sprayed calcium phosphate nanoparticles for neuroblastoma treatment

Niki Karouta – Post-Doc, Scilifelab; David Juriga – Post-Doc, Scilifelab; Georgios Sotiriou – Professor, Chemistry, Stockholm University
Introduction:

Neuroblastoma is a deadly cancer that primarily affecting children and urgently requires improved treatments [1]. Calcium phosphate (CaP) nanoparticles (NPs) are promising non-viral vectors due to their biocompatibility and low immunogenicity [2]. Their physicochemical properties enable efficient loading of diverse biological treatments (biologics) that are requiring advanced delivery systems to hold curative potential. Critically, particles and agglomerate size governs loading capacity, intracellular delivery and transfection efficiency [3].

Learning Objectives:

  • Recognize the advantages and opportunities of GD2 specific targeting for neuroblastoma treatment.
  • Explain the demonstrated PEGylation strategy for calcium phosphate nanoparticles.
  • Understand cell-NP interactions’ dependence on NP size and affinity binder density.