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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Poly(orthoester) (POE) Based Injectables

Edward Dobrzykowski – Senior Formulation Chemist, T&I, Celanese; Vijay Gyanani – Principal Formulation Chemist, T&I, Celanese; Jeffery Haley – Senior Manager, T&I, Celanese
Introduction:

Bioresorbable polymeric drug delivery systems can enhance adherence and therapeutic performance in short- and long-acting injectable formulations. Risperidone and bupivacaine were selected as model drugs to demonstrate tunable release kinetics. Poly(orthoester) (POE), a bioresorbable polymer with degradation times ranging from days to nearly one year, served as the delivery matrix. Release tunability was achieved by varying glycolide content and backbone substitution with 1,4-cyclohexanedimethanol (CHDM) for fast release or triethylene glycol (TEG) for slow release. CHDM-based POE enabled rapid bupivacaine release, while TEG-based POE provided sustained risperidone delivery.

Learning Objectives:

  • understand POE chemistry.
  • apply formulation strategies for POEs to tune the release kinetics to the desired profile.
  • execute formulation works in the lab.