Pterodon pubescens-Benth loaded microarray patches for targeted anti-inflammatory therapy

Ana Clara Brito Maria – PhD candidate, Faculty of Pharmaceutical Sciences, University of Campinas, Brazil; Sara Dobbin, PhD – Technical Services Co-ordinator, School of Biomedical Sciences, Ulster University, UK; Mary Ann Foglio, PhD – Professor, Faculty of Pharmaceutical Sciences, University of Campinas, Brazil; Rogério Machado – PhD candidate, Faculty of Pharmaceutical Sciences, University of Campinas, Brazil; Peter McPherson, PhD – Lecturer, School of Pharmacy and Pharmaceutical Sciences, Ulster University; Jessica Moore, PhD – Lecturer, School of Pharmacy and Pharmaceutical Sciences, Ulster University, UK; Fabiana Volpe-Zanutto, PhD – Lecturer, School of Biomedical Sciences, Ulster University

Introduction:

Brazil, recognised for its exceptional biodiversity, contains several ecologically rich regions which source bioactive natural products. Among these is Pterodon pubescens-Benth fruit (Pp) (sucupira), a native species traditionally used to treat inflammation, pain and rheumatism [1]. Recent research has highlighted broader pharmacological potential, including anti-inflammatory, analgesic and antiparasitic properties [2]. Systemic delivery of Pp- extract is limited by its poor solubility, posing challenges for effective applications, such as in arthritis therapies. This study reports on dissolving microarray patches (MAPs) as a novel delivery system for Pp-extract.