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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Protection against ischaemic-reperfusion injury with graphene oxide nanomaterials for nitric oxide delivery.

Tanveer Tabish – Research Fellow, Radcliffe Department of Medicine, University of Oxford
Introduction:

Ischaemic injury drives mitochondrial dysfunction and oxidative damage in cardiomyocytes (1). Nitric oxide (NO) is cardioprotective, however, its therapeutic use is limited by poor spatial control, short half-life and off-target effects. Achieving controlled, localised delivery of NO remains a challenge (2). Mitochondria-targeted NO has demonstrated protection against ischaemic-reperfusion (I/R) injury (3). Here, we have developed a mitochondria-targeted graphene oxide (GO) nanoassembly to enable NO storage, release and subcellular delivery in cardiomyocytes.

Learning Objectives:

  • Understand the roles nitric oxide and other gasotransmitters in disease pathology and therapeutic intervention
  • Explain how nanomaterial design enables controlled storage and release of gaseous therapeutics
  • Explore how subcellular targeting and controlled nitric oxide release modulate mitochondrial function