Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Designing Lipid Nanoparticles for RNA therapeutics

Kevin Fox – Doctoral student, UBC; Alex Birkenshaw – Doctoral student, UBC; Abishek Wadhwa – Doctoral student, UBC; Shuangyu Wang – Doctoral student, UBC; Anna Blakney – Assistant Professor, UBC; Pieter Cullis – Full Professor, UBC

Poster Presenter(s)

Suiyang Liao, PhD. (he/him/his)

Postdoc researcher
University of British Columbia
Vancouver, British Columbia, Canada

Introduction:

mRNA holds huge promise for future medicine and lipid nanoparticles (LNP) is currently the most advanced delivery vehicle for RNA drug. However, comparing to mRNA vaccines, delivering mRNA for therapeutic purpose requires higher translational potency (to produce more therapeutic proteins) and extend circulation half life (to achieve extrahepatic delivery). This report will discuss key structural features of LNPs and their indication in both potency and pharmacokinetics.

Learning Objectives:

Upon completion, participant will be able to understand how the heterogeneity of LNPs influences transfection.
Upon completion, participant will be able to gain insights on PK/BD of liposomal LNPs.