Dual-loaded nanoemulsion as a promising strategy for Candidozyma auris systemic infections

Gabriel Marena – Postdoc, University of São Paulo; Alejandro López – PhD candidate, Health Research Institute La Fe; Jose Manuel Pérez-Royo – Laboratory technician, Health Research Institute La Fe; Patricia Bernarbe – Laboratory technician, Health Research Institute La Fe; Maria Ángeles Tormo-Más – Researcher, Health Research Institute La Fe; Taís Maria Bauab – Professor, São Paulo State University; Marlus Chorilli – Professor, São Paulo State University; Javier Pemán – Professor, Health Research Institute La Fe; Alba Ruiz-Gatián – Researcher, Health Research Institute La Fe

Introduction: Candidozyma auris (formerly Candida auris) is an emerging yeast that has been increasingly associated with infections outbreaks, mainly systemic. It represents nowadays a global threat due to its high lethality, contagiousness, and resistance to major first-line antifungals like micafungin and amphotericin B. Therefore, the study of new therapeutic options is necessary. In this sense, the present study sought to develop nanoemulsion (NE) loaded with micafungin and amphotericin B (NEMA) as a resistance-free therapeutic option once NEs can protect and improve drugs efficiency.^[1]