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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Pulmonary delivery of pirfenidone-loaded succinylated gelatin-coated liposomes for pulmonary fibrosis therapy

Yuki Nakamura – doctoral student, Hokkaido University of Science; Sumio Chono – Proffesor, Hokkaido University of Science

    Poster Presenter(s)

  • Kohei Togami

    Associate Professor
    Hokkaido University of Science
    Sapporo, Hokkaido, Japan

Introduction:

Pulmonary fibrosis forms a collagen-rich extracellular matrix with increased protease activity, which may be exploited for lesion-selective delivery. We developed succinylated gelatin–coated liposomes (SG-lip) that bind to collagen and undergo matrix metalloproteinase (MMP)-responsive degradation, which prolongs pulmonary exposure to inhaled pirfenidone (PFD).

Learning Objectives:

  • Explain how collagen targeting and MMP responsiveness prolong lung exposure to inhaled pirfenidone.
  • Relate increased lung AUC to reduced hydroxyproline in bleomycin-induced pulmonary fibrosis.
  • Compare the antifibrotic outcomes of SG-lip with pirfenidone solution using the same dosing regimen.