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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Magrophage-derived hybrid lipid vesicles loaded with cyanocobalamin for antiinflammatory therapy enhancement

Melissa Merl – Msc Student, Goethe University Frankfurt; Antonio J. Guillot – Associate Professor, Farmacy and Pharmaceutical Technology, Universitat de València; Ana Melero – Professor, Farmacy and Pharmaceutical Technology, Universitat de València
Introduction:

Macrophages (MØ) are innate immune cells that regulate inflammation and immune responses mainly through proteins and receptors on their membranes (MMØ). These supramolecular structures are responsible for intercell communication, MØ tropism against inflamed tissue, cytokine secretion and MØ modulation to anti-inflammatory M2 phenotype. Biomimetic technology combines the innate bioactive features of cells with the therapeutic potential of synthetic nanoparticles Here, hybrid lipid vesicles combining synthetic phospholipids with RAW 264.7 MMØ were used to preserve MØ functions and enable cyanocobalamin (B12) delivery.

Learning Objectives:

  • to describe biomimetic macrophage hybrid vesicles.
  • to explain preparation and characterization of B12 hybrid vesicles.
  • o evaluate advantages of hybrid vesicles versus conventional liposomes.