Graduate Student Konkuk University, Republic of Korea
Introduction: Lipid nanoparticles (LNPs) have emerged as a clinically validated platform for the delivery of small interfering RNA (siRNA). A key component of LNP formulations is the ionizable lipid, which facilitates nucleic acid encapsulation and membrane destabilization under acidic endosomal conditions. However, ionizable lipid content has been linked to inflammatory responses and liver toxicity. Thus, strategies that reduce ionizable lipid content while preserving delivery performance are needed. This study investigates bile acid–histidine decapeptide conjugates as formulation additives for LNPs.
Learning Objectives:
Upon completion, participant will be able to evaluate peptide-based approaches for improving siRNA LNP safety.
