Thermostable Delivery of Recombinant VZV gE Vaccine Using Solid-Formulated Microneedle Patches

Jung-Hwan Park – Professor, Gachon University

Poster Presenter(s)

SEOJIN BYUN

Student
Gachon University, Republic of Korea

Introduction:

Varicella vaccination in children is still constrained by cold-chain requirements, injection-related discomfort, and safety concerns associated with live vaccines. Recombinant VZV glycoprotein E (gE) is a safer antigenic alternative, but its clinical utility depends on formulation strategies that preserve stability while enabling efficient skin delivery.

Learning Objectives:

Understand how solid-state microneedle formulations improve recombinant vaccine stability
Compare coated and powder-attached microneedle strategies for skin-targeted immunization
Recognize the translational advantages of thermostable microneedle vaccines for pediatric use