Assistant Professor Soongsil University, Seoul-t'ukpyolsi, Republic of Korea
Introduction: Perfluorocarbon (PFC)-based nanoemulsions have long been explored as artificial blood substitutes owing to their exceptional oxygen-carrying capacity. Despite extensive research, their clinical translation remains limited by insufficient formulation stability during storage and intravenous administration. This study investigates the instability of PFC nanoemulsions (PFC NEs) from a bulk rheological standpoint and proposes an additive-based strategy to improve long-term stability.
Learning Objectives:
Identify the role of bulk rheology in the long-term stability of PFC nanoemulsions.
Evaluate plasma volume expanders as stabilizers for injectable PFC nanoemulsions
Assess key physicochemical and biocompatibility requirements for clinical translation.
