Quantitative trajectory evaluation system for the adhesion and migration of porous microspheres on cell surfaces
Akihiro Matsumoto, Ph.D. – Professor, Osaka Ohtani University; Mikihisa Takano, Ph.D. – Professor, Yasuda Women's University; Yuta Hatori, Ph.D. – Associate Professor, Yasuda Women's University
Associate Professor Yasuda Women's University, Japan
Introduction: Porous microspheres (PMSs) have a remarkably low mass and density, large specific surface area, and excellent adsorption capacity. Therefore, they have various applications, including formulations for targeting the lungs [1] and stomach [2]. To develop PMSs as oral formulations, a simple experimentalmethod is required to quantitatively analyze their adhesion to the mucosal epithelium. Currently, there are analytical methods that utilize technologies such as quartz crystal microbalance and small-angle neutron scattering; however, these are not simple. We aimed to establish an in vitro evaluation system for quantitative analysis of the adhesion of PMSs to the mucosal epithelium.
Learning Objectives:
List the advantages of applying porous microspheres to oral formulations.
Describe a method for analyzing the adhesion and migration of porous microspheres on cell surfaces.
Describe the effects of adhesives and mucus on the gastrointestinal absorption of drugs from oral formulations.
