Associate Director Sanofi Waltham, Massachusetts, United States
Introduction: Vaccination is crucial for combating respiratory infectious diseases, yet conventional intramuscular vaccines primarily induce systemic immunity with limited mucosal protection. To overcome this, we designed a novel mRNA-lipid nanoparticle platform engineered for targeted mucosal delivery that significantly reduced lung viral loads and elicited strong systemic T cell and antibody responses across species.
Learning Objectives:
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Design
Develop
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Discover
Evaluate
Formulate
Infer
Recognize
Test
Theorize
Use
Verbalize
