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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Mechanistic Insights into Liposomal Disassembly: Effects of Serum Proteins, Lipid Exchange, and Drug Release

Camillo Benetti – Lecturer, Department of Pharmacy and Pharmaceutical Sciences, National University of Singapore; Matthias Gerhard Wacker – Professor, Department of Pharmaceutical and Pharmacological Sciences, Katholieke Universiteit Leuven, Belgium
Introduction:

Liposomes facilitated the delivery of small molecules, proteins, and nucleic acids and provide several benefits over conventional drug delivery systems (1, 2). One of the primary challenges of liposomes is understanding the key characteristics that influence their behaviour. Numerous studies have explored how liposomes affect various aspects of the delivery. However, the complex relationship between the disassembly of carrier and the drug release still requires further investigation. In this research, we integrated the disassembly of doxorubicin loaded PEGylated liposomes (Caelyx® and TLD) and lipid exchange mechanism with their subsequent drug release under various in vitro conditions.

Learning Objectives:

  • Evaluate the effect of serum protein concentrations on the carrier disassembly and drug release
  • Study the importance of lipid exchange mechanism for the phospholipid nanocarrier including lipid and drug release
  • Highlight the correlation between carrier disassembly and drug release from liposomes