Evaluation of thymol loaded phytosome and niosome formulations for lung cancer

Oya Kerimoğlu, T.C. – Prof. Dr., Pharmaceutical Technology, Marmara University; Özgül Gök Özatay, T.C. – Assoc. Prof., Faculty Of Engineering and Natural Sciences, Acıbadem University

Introduction:

Lung cancer is a major global health threat, with non-small-cell lung cancer comprising of 85% of cancer cases. [1,2] Conventional chemotherapy is often limited by systemic toxicity. [3] Thymol, which is a natural monoterpenoid and an important phenolic compound, exhibits potent anticancer activity. [4] Vesicular systems enable the delivery of therapeutic agents to specific target sites by enhancing treatment efficacy. [5] By determining the optimal formulation for niosomes and phytosomes, this study aims to develop a stable delivery system to improve the therapeutic potential of Thymol while minimizing systemic side effects.