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CRS 2026 Annual Meeting & Exposition Main banner

Skin and Mucosal Delivery (Focus Group – SMD)

Meso–Macro Porous Hydrogel-Based Microneedles for Direct Exosome Isolation and Release in Wound Healing

Nakwon Choi – Principal Investigator, Department of Biomedical Sciences, Korea University

    Poster Presenter(s)

  • Mina Kim, MS

    PhD candidate
    KU-KIST Graduate School of Converging Science and Technology
    Seoul, Republic of Korea

Introduction: Extracellular vesicles (EVs)/exosomes are promising wound-healing therapeutics, but their use is limited by laborious ultracentrifugation and multi-step preprocessing. We aim to translate a meso–macroporous PEGDA hydrogel EV-isolation matrix into a microneedle (MN) patch that can directly isolate bovine milk exosomes and release them immediately after insertion, enabling a simple “isolate-and-deliver” workflow for wound care.

Learning Objectives:

  • Understand meso–macro porous hydrogel microneedles for direct exosome isolation and release.
  • Explain the ultracentrifugation-free workflow for isolating milk exosomes using the microneedle platform.
  • Evaluate exosome isolation and wound-healing potential using size distribution and EV marker analyses.