Skip to main content
CRS 2026 Annual Meeting & Exposition Main banner

Manufacturing and Process Scale-Up

Development of liposomes loaded with Cannabis sativa extract using a quality-by-design approach

Nicole Ferrari de Carvalho – Undergraduate student, Universidade Estadual de Campinas (Unicamp); Janaína Artem Ataide – Professor, Universidade de São Paulo; Priscila Gava Mazzola – Associated professor, Universidade Estadual de Campinas (Unicamp)
Introduction: Liposomes are among the most studied nanostructured drug delivery systems due to their high biocompatibility, ability to encapsulate both hydrophilic and lipophilic compounds, and potential for targeted delivery. While most studies focus on synthetic drugs, the application of liposomal systems to complex natural extracts remains poorly understood (1), particularly regarding how critical material attributes and process parameters affect size and encapsulation efficiency. In this study, a quality-by-design approach was employed to investigate the influence of manufacturing parameters on liposomes loaded with a CBD-rich extract.

Learning Objectives:

  • Understand how a QbD approach elucidates the impact of manufacturing parameters on liposome properties
  • Assess how surfactant–extract interactions control vesicle size and lipophilic encapsulation
  • Apply QbD principles to the rational and reproducible design of natural product–based nanocarriers