Structure-Dependent Nicotine Release from Inkjet-Printed Buccal Films via Geometric Folding

Seong-Hun Jeong – student, Chungbuk National University; Woong-Young Jung – student, Chungbuk National University; Ji-Hyun Kang – Professor, Jeonbuk National University; Dong-Wook Kim – Professor, Wonkwang University; Chun-Woong Park – Professor, Chungbuk National University

Introduction: Nicotine replacement therapy (NRT) is widely used to alleviate withdrawal symptoms during smoking cessation. However, conventional products deliver fixed doses and show substantial interindividual variability in absorption, resulting in inconsistent systemic exposure and reduced adherence. Therefore, digital manufacturing strategies that enable precise dose personalization and predictable control of release kinetics are required. This study aimed to develop inkjet-printed nicotine buccal films and to investigate whether drug dose and release behavior can be quantitatively regulated through adjusting printing parameters and structural design.