In vitro drug release test for muco-adhesive formulations on muco-adhesive porous microspheres

Satoshi Murao – Assistant Professor, Osaka Ohtani University; Masayuki Kaneda – Associate Professor, Osaka Metropolitan University; Syou Maki – professor, Okayama University of Science; Takeo Kitazawa – Associate Professor, Yasuda Women's University; Yuta Hatori – Associate Professor, Yasuda Women's University; Akihiro Matsumoto – professer, Osaka Ohtani university

Introduction: Mucoadhesive formulations attach to the mucosa, allowing for efficient absorption. Attempts have been made to enhance the absorption of poorly absorbed drugs by imparting intestinal mucosal adhesion to the oral formulations. However, the intestinal fluid flows above the intestinal mucosa. Therefore, the drug and the absorption enhancers in the formulation are released and diluted by intestinal fluid [1](Figure 1), reducing the effectiveness of the absorption enhancers. It is necessary to evaluate the drug release behavior of mucoadhesive formulations in the gastrointestinal tract separately for the mucosa and intestinal fluid.