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Oral Delivery (Focus Group – OrD)

Cell Penetrating Peptide Engineered Liposomal Nanocarriers for Improved Oral Delivery of CNS-Targeted Asenapine

Srinivas Mutalik – Professor, Pharmaceutics, MCOPS; Alan Raj – Project Research Scientist, Pharmaceutics, MCOPS

    Poster Presenter(s)

  • Geethu M, PhD

    Project Research Scientist
    MCOPS
    Udupi, Karnataka, India

Introduction:

Oral delivery of Asenapine Malate (ASPM) is limited by poor solubility, low intestinal permeability, and extensive first-pass metabolism, resulting in very low bioavailability (< 2%) [1]. Liposomal carriers protect ASPM from gastrointestinal degradation and improve epithelial transport, but unmodified liposomes show limited uptake. Surface functionalization with TAT cell-penetrating peptide (CPP) enhances trans-epithelial transport and cellular internalization via CPP-mediated mechanisms, improving systemic absorption [2,3]. This study evaluates TAT-functionalized liposomal systems for enhanced gastrointestinal transport and oral bioavailability of ASPM.

Learning Objectives:

  • Describes how TAT CPP functionalization enhances liposomal epithelial transport and cellular uptake of ASPM.
  • Evaluate the effects of TAT surface modification on ASPM release profile, biocompatibility, and absorption.