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Oral Delivery (Focus Group – OrD)

Development of Amorphous Solid Dispersions of Dapsone for Improved dissolution and Oral Bioavailability

Sanskruti Jadhav, M. Pharm – Student, Pharmaceutics, School of Pharmacy, Indira University; Vaishali Shirsat, Ph D (Tech) – Associate Professor, Pharmaceutical Analysis, Bombay College of Pharmacy; Suhas Yewale – Consultant, Image ProVision Pvt Ltd; Poonam Desale, M.Pharm – Student, Pharmaceutical Analysis, Bombay College of Pharmacy
Introduction:

Dapsone (DAP), a weakly basic bacteriostatic sulfone, is used for treating infectious & other inflammatory diseases. DAP can also be repurposed for treating various cancers. However, its poor aqueous solubility and dissolution in the gut fluids limit its oral bioavailability. Carboxymethyl ethyl cellulose (CMEC) is a less explored enteric polymer with potential applications in oral drug delivery. This study focuses on developing CMEC-DAP amorphous solid dispersions (ASDs) and optimizing the composition of ASDs using microscopic image analysis tools, followed by in vitro and in vivo studies.

Learning Objectives:

  • Demonstrate the potential of microscopic image analysis for polymer selection and method optimization for ASDs.
  • Establish the promise of CMEC, a less explored enteric polymer, for the preparation of ASDs
  • Demonstrate the effect of ASDs on oral bioavailability improvement of hydrophobic drugs