Introduction: The accumulation of subcutaneous adipose tissue presents health and aesthetic concerns, while existing fat reduction strategies are limited by invasiveness. Polymer–lipid hybrid nanoparticles (PLNs) provide an alternative approach by combining polymeric stability with lipid-associated cellular interactions. In particular, fatty acids (FAs) are actively involved in adipocyte metabolism and can enhance selective cellular uptake. In this study, we investigated sonographically monitorable FA-modified PLNs designed to induce effectively adipose tissue reduction through intracellular gas generation.
Learning Objectives:
Efficient delivery can be achieved through the active fatty acid consumption of adipocytes.
Nanoparticle activity of gas-generating polymer–lipid hybrid nanoparticles can be monitored by sonography.
