Development of a Controlled Porosity Osmotic Pump (CPOP) Zero-Order Release tablet in lieu of a Laser Drilled Orifice
Raj Arunagiri – Global Marketing Manager, Pharma, Eastman; Ankikumar Jain, PhD – Application Development and Technical Services Lead, Pharma, Eastman; Matt Stephens, PhD – Group Leader, Personal Care, Eastman
Introduction: Osmotic pump delivery is the only oral technology capable of true zero‑order release, but costs of laser orifice drilling and tablet core construction are primary drivers preventing its adoption. Controlled-Porosity Osmotic Pump (CPOP) coating systems utilize a water-soluble component imbedded in a semi-permeable cellulose acetate film to create microchannels that facilitate drug release in lieu of a laser drilled hole and thus reduce market entry barriers. This study explores how variations in coating formulation and coating parameters impact the release rate of a CPOP tablet film and the feasibility of developing a zero-order extended release CPOP metoprolol succinate tablet formulation.
Learning Objectives:
Understand the impact of CPOP formulation/process variables on drug release
Explain the relationship of process variables to coating microstructure and drug release
