Controlled release acceleration of a lipophilic drug from PEVA-based implants using hydrophilic additives

Andriy Dashevskiy – Private Lecturer, Pharmaceutical Technology, Freie University Berlin; Anne Seidlitz, Prof – Professor, Pharmaceutical Technology, Freie Universität Berlin; Roland Bodmeier – Profssor (in retirement); managing director, Freie University Berlin; Pensatech Pharma

Introduction: Polyethylene vinyl acetate (PEVA) is investigated as carrier polymer for long-acting drug delivery. However, low release rates can limit its applicability for some drugs (1). The addition of lactose can increase drug release rate by acting as a pore-former (2). This study aims to evaluate the potential of drug release acceleration by lactose addition into a PEVA-matrix implant.