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Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Peroxidase-Mimicking Nanozymes Coupled with Receptor-Mediated Targeting for Breast Cancer Therapy

Prashant Mishra – Professor, Department of Biochemical Engineering and Biotechnology, Indian Institute of Technology Delhi, India
Introduction:

According to the American Cancer Society Breast Cancer Facts & Figures 2024-2025 statistics, about 316,950 new invasive breast cancer cases occurred in U.S. women, with ~42,170 women dying from the disease. Challenges in the conventional treatment include non-specific drug delivery, the requirement for higher doses, and unwanted side effects. The current study aims to develop a targeted nanotherapeutic strategy that combines enzyme-mimetic activity, prodrug activation, and receptor-mediated uptake to selectively kill breast cancer cells while minimizing toxicity to normal cells.

Learning Objectives:

  • Upon completion, participant will be able to describe how nanozyme systems enable targeted prodrug activation.
  • Upon completion, participant will be able to explain the role of lysosomal drug delivery.
  • Upon completion, participant will be able to define therapeutic efficacy using 2D cultures and 3D tumor spheroids.