Scalable Supercritical Fluid–Based Manufacture of Amorphous Esomeprazole for Improved Oral Delivery

Chang-Seon Myung – Professor, College of Pharmacy, Chungnam National University; Hwa-Young Son – Professor, College of Veterinary Medicine, Chungnam National University

Poster Presenter(s)

Jeong-Sook Park, JS

Professor
Chungnam National University, Republic of Korea

Introduction:

Poor aqueous solubility remains a major limitation in oral delivery of many drugs, including esomeprazole magnesium (ESM). Conventional amorphous formulations often rely on organic solvents and batch processes, presenting challenges in scalability, residual solvent control, and environmental sustainability. Supercritical fluid technologies offer a green alternative enabling precise particle engineering with minimal solvent use.

Learning Objectives:

To understand the role of supercritical fluid technologies in scalable oral drug formulation manufacturing.
To evaluate how particle morphology and solid-state properties influence dissolution and bioavailability.
To understand the benefits of green, solvent-reduced processes for pharmaceutical development and scale-up.