Introduction: The potential for mRNA therapeutics holds much more promise to deliver, such as cancer treatments (e.g. CAR-T) and gene editing for treating diseases (e.g. CRISPR). These all are enabled by nano-delivery systems for targeted and controlled delivery. However, there are significant challenges to pass through clinical trials, mostly stemming from not understanding the complexity of your formulation during scale-up. For active targeted formulations, this is additionally more complex by attaching targeting moieties to the surface. These challenges require novel tools to deal with the sub-populations within formulations and to also understand their behaviour in the body via the protein corona.
Learning Objectives:
Upon completion, participant will be able to understand how to utilize chromatography for LNP-based formulations.
Upon completion, participant will be able to use chromatography to analyze their targeted LNP formulations.
Upon completion, participant will be able to understand how to properly study their protein corona around LNPs.
