Skip to main content
CRS 2026 Annual Meeting & Exposition Main banner

Skin and Mucosal Delivery (Focus Group – SMD)

Volatile Oil-Based Baicalin Nano-Phytogel for Enhanced Antioxidant and Anti-Inflammatory Psoriasis Therapy

Rahul Shukla – Assistant Professor, Pharmaceutics, NIPER-Raebareli
Introduction:

Psoriasis is a chronic inflammatory skin disorder characterised by elevated oxidative stress (1). Baicalin exhibits well-documented antioxidant and anti-inflammatory activity but suffers from poor aqueous solubility, low skin permeability, and limited topical bioavailability (2). This study aimed to rationally design an essential oil-based nano-phytogel using rosemary oil as a functional lipid excipient to enhance baicalin stability, cutaneous delivery, and therapeutic performance in inflammatory skin conditions (Fig. 1a).

Learning Objectives:

  • Describe the design principles of volatile oil–based nano-phytogels for psoriasis therapy.
  • Explain nano-enabled modulation of oxidative stress and inflammatory signaling by baicalin.
  • Interpret dermatokinetic parameters to assess topical nanocarrier drug disposition.