doctoral candidate University Würzburg Würzburg, Bayern, Germany
Introduction: Carbohydrate-functionalized nanomaterials offer powerful opportunities to modulate biological interactions through controlled surface glycosylation. Structurally related monosaccharides such as mannose, galactose, galactosamine and glucosamine can exhibit markedly different affinities toward carbohydrate-recognizing receptors despite their close chemical similarity [1]. However, systematic platforms enabling direct bottom-up synthesis and comparison of these glycans within otherwise comparable nanostructures are limited. Here, we present a modular polymer-based approach for systematic generation and comparison of nanogels bearing distinct surface carbohydrates.
Learning Objectives:
Bottom-up nanogel synthesis and architectures enable systematic comparison of related carbohydrate ligands.
Describing the role of glycan identity and nanogel formation in driving receptor-specific cellular interactions.
Evaluating glycosylated nanogels for targeted delivery to carbohydrate receptor-expressing cells.
