Systemic Nasal Absorption of Supersaturating Amorphous Solid Dispersions for Rapid Drug Onset

Slavomira Doktorovova – Senior Scientist, Hovione; Ana Fortuna – Professor, University of Coimbra; Dina Morais – Senior Scientist, Hovione

Introduction:

Poorly soluble drugs often exhibit limited and variable absorption following nasal administration. Amorphous solid dispersions can enhance drug solubility by generating supersaturated solutions upon contact with the nasal mucosa, promoting rapid systemic uptake [1]. Mucoadhesive polymers may further influence supersaturation maintenance and absorption. This study aimed to evaluate the impact of polymer selection on the in vitro dissolution, ex vivo permeation, and in vivo pharmacokinetics of spray‑dried amorphous nasal powders containing piroxicam [2].