Ionic liquid 1 enhances nasal absorption of dextran as a model of mid-sized macromolecule

Shoichiro Fukuda – Student, Department of Pharmacokinetics and Biopharmaceutics, Tokushima University; Haruka Takata – Assistant Professor, Department of Pharmacokinetics and Biopharmaceutics, Tokushima University; Takashi Nakae – Researcher, MEDRx Co., Ltd; Noboru Tatsumi – Researcher, MEDRx Co., Ltd; Hidetoshi Hamamoto – Researcher, MEDRx Co., Ltd; Shingo Kobayashi – Associate Professor, Department of Pharmacokinetics and Biopharmaceutics, Tokushima University; Hidenori Ando – Associate Professor, Department of Pharmacokinetics and Biopharmaceutics, Tokushima University; Tatsuhiro Ishida – Professor, Department of Pharmacokinetics and Biopharmaceutics, Tokuhsima University

Introduction:

Ionic liquids are organic salts composed of organic cations and organic/inorganic anions, with melting points below 100℃. Recently, ionic liquids have gained attention in the pharmaceutical field for their ability to solubilize active pharmaceutical ingredients and improve bioavailability mainly in transdermal administration. We showed that the ionic liquid 1 (IL1) we possess causes oral absorption of a 10 kDa dextran, which have never absorbed through from intestine. Herein, we aimed to expand the utility of ionic liquids for nasal absorption of mid-sized macromolecules.

Learning Objectives:

• Upon completion, participants will be able to explain up to what molecular ionic liquid enhance nasal absorption.