Puncturing Acne via Dissolving Minocycline Microneedles: From Fabrication to Antibacterial Performance

Suha Abodoleh – Associate Professor, Middle East University; Nisreen Dahshan – Assistant Professor, Isra University, Jordan; Dima Lafi – Research Assistant, Isra University, Jordan

Introduction:

Acne is a highly prevalent skin disorder, affecting more than 85% of individuals worldwide. It is an inflammatory cutaneous condition that impairs patients’ quality of life and is often associated with psychological consequences such as depression, anxiety and social distress. The development of effective and safe acne treatments is essential. Recently, minocycline-loaded microneedles have been explored to enable localized drug delivery while minimizing systemic side effects. However, previously reported fabrication methods are complex, limiting scalability. This study aims to develop minocycline microneedles using a simple, cost-effective, and scalable approach as shown in Figure 1.