Polyethylene glycol-polyester branched copolymers as ingredient for long-acting injectable formulations

Charlotte Peloso – Senior Research and Innovation Associate, Medincell; Adolfo Lopez-Noriega – Head of Research and Development, Medincell

Introduction: Bioresorbable in situ forming technologies represent the ideal choice for delivering active ingredients at the therapeutic plasmatic concentration for treatments with repeated dosing. These injectable products can form a solid depot upon administration into an aqueous environment, entrapping a drug and ensuring its diffusion over an extended period (1). For efficient controlled release, physicochemical parameters of the formulation ingredients should be finely tuned. Here, the effect on performance of branched copolymers (2) compared to linear structures used in the BEPO® technology (3) with similar size and hydrophobic to hydrophilic ratio was explored.