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Skin and Mucosal Delivery (Focus Group – SMD)

Microfluidic Hybrid-Nanoparticles Integrated into Dissolvable Microneedles for Targeted Skin Immunotherapy

Thiecla Katiane Rosales – Post Doc, Department of Biomaterials and Biomedical Technology (BBT), The University Medical Center Groningen (UMCG); Maria Lobita – Phd student, Department of Biomaterials and Biomedical Technology (BBT), The University Medical Center Groningen (UMCG); Hélder Santos – Full Professor and Head of Department, Department of Biomaterials and Biomedical Technology (BBT), The University Medical Center Groningen (UMCG)
Introduction: Hybrid nanoparticles are promising platforms for transdermal immunomodulation, but translation is limited by control over quality attributes and integration with delivery systems. This study investigates hybrid nanoparticles with a PLGA core and a lipid shell designed for incorporation into dissolvable microneedle arrays for transdermal delivery of immunomodulators combined with siRNA, aiming at scalable, reproducible, and skin-compatible formulations for psoriasis treatment. 

Learning Objectives:

  • Describe how microfluidic parameters control hybrid nanoparticle quality for reproducible transdermal delivery.
  • Highlight the importance of precise manufacturing for safe, skin-compatible immunomodulatory nanoparticles.
  • Assess formulation and process trade-offs affecting nanoparticle–microneedle integration and scalability.