Development of SNEDDS to improve the bioavailability of a new antileishmanial drug
Luis Junior Barrionuevo Quintana – Student, Complutense University of Madrid; Christophe Dardonville – Researcher (PI), Institute of Medicinal Chemistry, IQM−CSIC; Almudena Laguna – PhD student, Complutense University of Madrid; Santiago Torrado – Professor, Complutense University of Madrid; Adriana Oliveira Santos – Researcher RISE-Health, Universidade da Beira Interior
Associate professor Complutense University of Madrid Madrid, Madrid, Spain
Introduction: In this work, different formulations were developed to enhance the solubility and reduce precipitation of the novel oral antileishmanial drug JNII40 in the gastrointestinal medium. The use of self-nanoemulsifying drug delivery systems (SNEDDS) may represent a potential approach to improve drug bioavailability (1). Upon dispersion, these systems result in small particle sizes that can decrease precipitation and enhance gastrointestinal transport (2).
Learning Objectives:
Development of a new formulation for oral administration of a new antileishmanial drug.
Evaluate the intestinal precipitation of JNII40 in SNEDDS developed formulations.
Compare the pharmacokinetic parameters of JNII40 raw material and in SNEDDS formulations.
