Oral Protein Delivery for the Local Treatment of Crohn’s Disease Using Targeted Supramolecular Nanoparticles

Sonia Pedro, Dr – Postdoctoral Researcher, School of Pharmacy, University of Nottingham; Aimee Scott, MSci – PhD Student, University of Nottingham; Veeren Chauhan, Dr – Assisstant Professor, School of Pharmacy, University of Nottingham; Felicity de Cogan, Dr – Associate Professor, School of Pharmacy, University of Nottingham

Introduction:

Crohn’s disease (CD) is a chronic inflammatory bowel disease characterised by a relapsing-remitting course and transmural inflammation throughout the gastrointestinal tract [1]. While oral delivery of biologics offers a promising approach for localised therapy, its clinical application remains limited by gastric instability, enzymatic degradation, and poor intestinal permeability [2]. To overcome these challenges, this study leverages recent advances in supramolecular nanoparticle assembly to develop a “nano-in-gel” platform for targeted protein delivery [3].