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CRS 2026 Annual Meeting & Exposition Main banner

Nanomedicine and Nanoscale Delivery (Focus Group – NND)

Flame-made nanoparticles for FcRn-mediated miRNA delivery in chemoresistant colorectal cancer therapy

Georgios Sotiriou – Principal Investigator, SciLifeLab; Bruno Sarmento – Principal Investigator, i3S-Instituto de Investigação e Inovação em Saúde

    Poster Presenter(s)

  • Natália Teixeira

    PhD Student
    Instituto de Investigação e Inovação em Saúde (i3S)
    Porto, Porto, Portugal

Introduction:

Colorectal cancer (CRC) remains a significant global health challenge, with chemotherapy often compromised by drug resistance linked to dysregulated microRNA (miRNA) profiles1. Restoring physiological miRNA levels offers a promising strategy to reverse resistance. Despite this potential, oral miRNA delivery is limited by gastrointestinal degradation and poor targeting2. To address these limitations, we are developing a nanotherapy that exploits the neonatal Fc receptor (FcRn), overexpressed in CRC tissues3, to enhance delivery specificity and chemosensitivity.

Learning Objectives:

  • Describe the challenges of oral miRNA delivery and strategies to enhance stability and specificity.
  • Describe how targeting FcRn improves the efficacy of orally administered therapeutics in CRC.
  • Describe how miRNA modulation of drug resistance enhances treatment efficacy when combined with chemotherapy.