Sargassum fusiforme–Derived Exosome-Like NVs Enhance Osteogenesis, Suppress Osteoclastogenesis in OVX Mice

Jae-Hee Kwon – PhD student, Gyeongkuk National University; Dong-ha Kim – Postdoc, Gyeongkuk National University; Young-Eun Cho – Professor, Gyeongkuk National University; Dokyun Kim – Professor, Jeonbuk National University

Introduction:

Osteoporosis is driven by uncoupled bone remodeling, causing bone loss and fragility after estrogen decline. Long-term antiresorptive may raise safety concerns, motivating safer, naturally derived approaches. We evaluated Sargassum fusiforme–derived exosome-like nanovesicles (S.F-NVs) as an orally deliverable marine nanotherapeutic to restore remodeling balance by enhancing osteoblast activity and limiting osteoclast formation, with focus on BMP–Smad1/5/8 and mitogen-activated protein kinase signaling.